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KMID : 0605720060120020252
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Journal of the Korean Society of Biological Therapies in Psychiatry
2006 Volume.12 No. 2 p.252 ~ p.267
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Effect of Caffeine on Sleep and EEG Spectra in Rats
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Kwon Do-Hoon
Won Seung-Hee
Kim Ki-Min
Chang Su-Min
Kim Sang-Heon
Lee Maan-Gee
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Abstract
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Caffeine induces arousal and reduces slow-wave activity of the cortex by blocking adenosine action on the adenosine receptor. Caffeine induces dose-dependent arousal. Therefore, caffeine-induced arousal may be a different state from an arousal in waking subjects. So we compared EEG spectra between of a state produced by intraperiotoneal caffeine injection and of a state produced by 3-hour sleep deprivation.
A total of 8 Sprague-Dawley male rats underwent EEG/EMG recording session from 10：30 to 17：30. They received intraperitoneal caffeine injection(7.5, 15, and 30mg/kg) at 13：30 and some cases received sleep deprivation from 10：30 to 13：30.
Caffeine dose-dependently reduced the duration of slow-wave sleep and increased the duration of waking state. The increase of waking state resulted from the increase of maintanence of the state while the reduction of sleep state resulted from the decrease of transition from waking to sleep. Sleep deprivation did not show rebound increase of sleep but it decreased the period of paradoxical sleep. In spectral profile, sleep deprivation increased relative proportion of delta activity and both caffeine and sleep deprivation decreased relative proportion of power in alpha band and increased in gamma band. Caffeine decreased the absolute power of delta and alpha bands and increased absolute power of gamma band which was more prominent in the frontal cortex.
In conclusion, caffeine promoted waking state by acceleration of transition to waking state from other states which was reverse in sleep deprivation. Therefore, adenosine may accumulate during sleep deprivation and mediate sleep pressure and caffeine may block its action on the adenosine receptor. The comparison of the spectral profiles indicates that caffeine-induced waking state may differ from normal awake state and from awake state after sleep deprivation.
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KEYWORD
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Caffeine, Sleep-wake regulation, EEG, Spectrum, Adenosine, Sleep deprivation
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